Metabolism of Polycyclic Compounds 21. THE METABOLISM OF PHENANTHRENE IN RABBITS AND RATS: DIHYDRO- DIHYDROXY COMPOUNDS AND RELATED GLUCOSIDURONIC ACIDS BY E. BOYLAND AND P. SIMS
نویسنده
چکیده
It was shown by Young (1947) and by Boyland & Wolf (1950) that rats convert phenanthrene into trans 9,10 dihydro-9,10 dihydroxyphenanthrene; the latter workers further showed that rabbits convert phenanthrene into this compound and also into trans-1,2-dihydro-1,2-dihydroxyphenanthrene. Bergel & Pschorr (1903) had found that phenanthrene causes an increased excretion of glucuronic acid conjugates. In the present work it was found that the above compounds, together with trans3,4-dihydro-3,4-dihydroxyphenanthrene, are excreted both free and conjugated with glucuronic acid in animals of both species. Glucuronic acid conjugates of hydroxyphenanthrenes and of dihydroxyphenanthrenes are also present.
منابع مشابه
Metabolism of polycyclic compounds. 20. The metabolism of phenanthrene in rabbits and rats: mercapturic acids and related compounds.
Investigations on rats dosed with phenanthrene (Elson, Goulden & Warren, 1945; Crabtree, 1946) showed that there was an increase in the neutralsulphur output in tihe urines, and Gutmann & Wood (1950) found an increase in the radioactivity in the urines when animals were fed with phenanthrene and L-[35S]cysteine. Stekol (1935, 1939) had noticed that the growth of dogs and rats was retarded when ...
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